Molecular and histopathological landscape of 131 meningiomes: a retrospective institutional study with knowledge from Cimpact-now

Background:

The forecast in meningiomes has traditionally been based on histopathological classification, which has inherent restrictions, including the variability of the interobs server, the intratumoral heterogeneity and inconsistent correlation with clinical behavior. While molecular profil creation improves diagnostic precision and risk stratification, it is not yet routinely used in clinical practice. So far, no molecular data on meningiomes from our country have been published. This study aims to take this gap into account by characterizing the molecular landscape of meningiomes at our institution and taking insights from the latest Cimpact now updates.

Methods:

We analyzed retrospectively consecutive 131 meningiomes, which were subjected to molecular sequencing between 2021 and 2023. Tumors were classified according to the latest WHO criteria. The sequencing of the next generation (NGS) was carried out using the OnComine Comprehensive Assay, a targeted panel for solid tumors. The molecular findings correlated with clinical pathological parameters.

Results:

The cohort comprised 84 women and 47 men (average age: 51 years; area: 2-79). The tumor points included cerebral convexity (45.8%), the skull base (38.2%), the rear fossa (3.1%) and the spine (5.3%), with 7.6%multifocal being. CNS, the tumors of grade 2 were most common (58%), followed by grade 1 (35%) and degrees 3 (7%). NF2 Changes (35%) were the most common and performed more frequently in all classes in classes 2 and 3, and the WHO degree (p = 0.002) were significantly associated with the tumor location: NF2 Changes threatened to convex and spine, while Trakl's mutations (mutations (TransformerPresent Act1Present KLF4Present We) were enriched in deep skull base tumors. Homozygot with high risk CDKN2A/B The deletions were unexpectedly identified in a tumor of 3 degrees 3 with hemonygic deletions in three tumors of 2 degrees 2.

Diploma:

This study offers regional insights into the molecular landscape of meningiomes in our population. While the routine molecular profil creation increases added value for classification and forecast, wider implementation can be restricted by cost and panel cover restrictions.